SeattleSeq Annotation 150
  

SeattleSeq Annotation

The SeattleSeq Annotation server provides annotation of SNVs (single-nucleotide variations) and small indels, both known and novel. This annotation includes dbSNP rs IDs, gene names and accession numbers, variation functions (e.g. missense), protein positions and amino-acid changes, conservation scores, HapMap frequencies, PolyPhen predictions, and clinical association.

Data from a number of sources has been pooled to create a local database from which many of the properties are drawn. This is the same database that is used by the Genome Variation Server (GVS).


CADD scores are Copyright 2013 University of Washington and Hudson-Alpha Institute for Biotechnology (all rights reserved) but are freely available for all academic, non-commercial applications. For commercial licensing information contact Jennifer McCullar (mccullaj@uw.edu). CADD is currently developed by Martin Kircher, Daniela M. Witten, Gregory M. Cooper, and Jay Shendure (http://cadd.gs.washington.edu)."

This site is supported by the National Heart, Lung and Blood Institute (NHLBI).

Please see the terms of service.

The site is briefly described in this publication: Nature 2009 Sep 10;461(7261):272-6, Targeted capture and massively parallel sequencing of 12 human exomes, S. B. Ng et al.
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